Naturally small Dirac neutrino masses in supergravity

We show that Dirac neutrino masses of the right size can arise from the Kahler potential of supergravity. They are proportional to the supersymmetry and the electroweak breaking scales. We find that they have the experimentally observed value provided that the ultraviolet cut-off of the Minimal Supersymmetric Standard Model (MSSM) is between the Grand Unification (GUT) scale and the heterotic string scale. If lepton number is not conserved, then relatively suppressed Majorana masses can also be present, resulting in pseudo-Dirac neutrino masses.Comment: 6 pages, Revtex 4, published versio

Noncommutativity from the string perspective: modification of gravity at a mm without mm sized extra dimensions

We explore how the IR pathologies of noncommutative field theory are resolved when the theory is realized as open strings in background B-fields: essentially, since the IR singularities are induced by UV/IR mixing, string theory brings them under control in much the same way as it does the UV singularities. We show that at intermediate scales (where the Seiberg-Witten limit is a good approximation) the theory reproduces the noncommutative field theory with all the (un)usual features such as UV/IR mixing, but that outside this regime, in the deep infra-red, the theory flows continuously to the commutative theory and normal Wilsonian behaviour is restored. The resulting low energy physics resembles normal commutative physics, but with additional suppressed Lorentz violating operators. We also show that the phenomenon of UV/IR mixing occurs for the graviton as well, with the result that, in configurations where Planck's constant receives a significant one-loop correction (for example brane-induced gravity), the distance scale below which gravity becomes non-Newtonian can be much greater than any compact dimensions.Comment: 30 pages. Slight revision: clarified some points and added a referenc

Identification of rare-earth minerals associated to K-feldspar: Capacsaya project in Peru

A recently discovered the rare-earth-rich site in Capacsaya, located at 123 km northwest of Cusco, at the south of Peru, contains significant quantities of light and heavy rare-earth elements such as neodymium, lanthanum, cerium, europium, and yttrium. This work reports the identification of rare-earth elements and their associated minerals using scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray diffraction analyses. Five (5) samples extracted from different locations at the Capacsaya site were characterized and identified K-feldspar as the mineral associated with the rare-earth elements in a representative sample with a high concentration of lanthanum and cerium. The results showed rare-earth elements contained within the mineral phase monazite, being cerium the dominant element in the phase (La, Ce, Nd)PO4. Finally, through the electrostatic separation process we demonstrate that it was possible to achieve an efficient separation of the K-feldspar phase in the particle size range 75–150 μ m.Fil: Ochoa, J.. Universidad Nacional de Ingeniería; PerúFil: Monteblanco, E.. Commissariat A L Energie Atomique Et Aux Energies Alternatives.; FranciaFil: Cerpa, L.. Instituto Geológico Minero y Metalúrgico; PerúFil: Gutarra Espinoza, Abel. Universidad Nacional de Ingenieria; PerúFil: Aviles Felix, Luis Steven. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentin

Direct Mediation and Metastable Supersymmetry Breaking for SO(10)

We examine a metastable $\mathcal{N}=1$ Macroscopic SO(N) SQCD model of Intriligator, Seiberg and Shih (ISS). We introduce various baryon and meson deformations, including multitrace operators and explore embedding an SO(10) parent of the standard model into two weakly gauged flavour sectors. Direct fundamental messengers and the symmetric pseudo-modulus messenger mediate SUSY breaking to the MSSM. Gaugino and sfermion masses are computed and compared for each deformation type. We also explore reducing the rank of the magnetic quark matrix of the ISS model and find an additional fundamental messenger.Comment: 43 pages, Latex. Version to appear in JHEP

Realism of Lagrangian Large Eddy Simulations Driven by Renalysis Meteorology: Tracking a Pocket of Open Cells Under a Biomass Burning Aerosol Layer

An approach to drive Lagrangian large eddy simulation (LES) of boundary layer clouds with reanalysis data is presented and evaluated using satellite (Spinning Enhanced Visible and Infrared Imager, SEVIRI) and aircraft (Cloud‐Aerosol‐Radiation Interactions and Forcing, CLARIFY) measurements. The simulations follow trajectories of the boundary layer flow. They track the formation and evolution of a pocket of open cells (POC) underneath a biomass burning aerosol layer in the free troposphere. The simulations reproduce the evolution of observed stratocumulus cloud morphology, cloud optical depth, and cloud drop effective radius, and capture the timing of the cloud state transition from closed to open cells seen in the satellite imagery on the three considered trajectories. They reproduce a biomass burning aerosol layer identified by the in‐situ aircraft measurements above the inversion of the POC. Entrainment of aerosol from the biomass burning layer into the POC is limited to the extent of having no impact on cloud‐ or boundary layer properties, in agreement with the CLARIFY observations. The two‐moment bin microphysics scheme used in the simulations reproduces the in‐situ cloud microphysical properties reasonably well. A two‐moment bulk microphysics scheme reproduces the satellite observations in the non‐precipitating closed‐cell state, but overestimates liquid water path and cloud optical depth in the precipitating open‐cell state due to insufficient surface precipitation. A boundary layer cold and dry bias occurring in LES can be counteracted by reducing the grid aspect ratio and by tightening the large scale wind speed nudging towards the surface. </div

<i>Plasmodium </i>Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission

Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine the role of SMC2 and SMC4, the core subunits of condensin, during endomitosis in schizogony and endoreduplication in male gametogenesis. During early schizogony, SMC2/SMC4 localize to a distinct focus, identified as the centromeres by NDC80 fluorescence and chromatin immunoprecipitation sequencing (ChIP-seq) analyses, but do not form condensin I or II complexes. In mature schizonts and during male gametogenesis, there is a diffuse SMC2/SMC4 distribution on chromosomes and in the nucleus, and both condensin I and condensin II complexes form at these stages. Knockdown of smc2 and smc4 gene expression reveals essential roles in parasite proliferation and transmission. The condensin core subunits (SMC2/SMC4) form different complexes and may have distinct functions at various stages of the parasite life cycle

Projected Changes to Wintertime Air‐Sea Turbulent Heat Fluxes Over the Subpolar North Atlantic Ocean

In wintertime over the subpolar North Atlantic Ocean (SPNA), the strongest surface sensible and latent heat fluxes typically occur just downstream of the sea-ice edge. The recent retreat in Arctic wintertime sea ice is changing the distribution of these turbulent heat fluxes, with consequences for the formation of the dense waters that feed into the Atlantic Meridional Overturning Circulation. Projections of turbulent heat flux over the SPNA are investigated using output from the HadGEM3-GC3.1 climate model, produced as part of the sixth phase of the Coupled Model Inter-Comparison Project. Comparison of two model resolutions (MM: 60 km atmosphere—1/4° ocean and HH: 25 km–1/12°) shows that the HH configuration more accurately simulates historic sea ice and turbulent heat flux distributions. The MM configuration tends to produce too much sea ice in the SPNA, affecting the turbulent heat flux distribution; however, it displays improved performance during winters with less sea ice, increasing confidence in future projections when less sea ice is predicted. Future projections are presented for low (SSP1-2.6) and high (SSP5-8.5) emissions pathways. The simulations agree in predicting that, with climate change, the SPNA will see reductions in wintertime sea ice and air-sea turbulent fluxes later in the 21st century, particularly in the Labrador and Irminger Seas and the interior of the Nordic Seas, and a notable reduction in their decadal variability. These effects are more severe under the SSP5-8.5 pathway. The implications for SPNA ocean circulation are discussed

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity for activation enhancers or coagonists. In contrast, the MHCI-restricted cells studied to date show no such peptide specificity for coagonists, suggesting that CD8 binding to noncognate MHCI is more important. Here we show how this dichotomy can be resolved by varying CD8 and TCR binding to agonist and coagonists coupled with computer simulations, and we identify two distinct mechanisms by which CD8 influences the peptide specificity of coagonism. Mechanism 1 identifies the requirement of CD8 binding to noncognate ligand and suggests a direct relationship between the magnitude of coagonism and CD8 affinity for coagonist pMHCI. Mechanism 2 describes how the affinity of CD8 for agonist pMHCI changes the requirement for specific coagonist peptides. MHCs that bind CD8 strongly were tolerant of all or most peptides as coagonists, but weaker CD8-binding MHCs required stronger TCR binding to coagonist, limiting the potential coagonist peptides. These findings in MHCI systems also explain peptide-specific coagonism in MHCII-restricted cells, as CD4–MHCII interaction is generally weaker than CD8–MHCI.National Institutes of Health (U.S.). Pioneer Awar